Control of actin-based motility through localized actin binding
نویسندگان
چکیده
منابع مشابه
Mechanism of actin-based motility.
Spatially controlled polymerization of actin is at the origin of cell motility and is responsible for the formation of cellular protrusions like lamellipodia. The pathogens Listeria monocytogenes and Shigella flexneri, which undergo actin-based propulsion, are acknowledged models of the leading edge of lamellipodia. Actin-based motility of the bacteria or of functionalized microspheres can be r...
متن کاملControl of actin dynamics in cell motility.
Actin polymerization plays a major role in cell movement. The controls of actin sequestration/desequestration and of filament turnover are two important features of cell motility. Actin binding proteins use properties derived from the steady-state monomer-polymer cycle of actin in the presence of ATP, to control the F-actin/G-actin ratio and the turnover rate of actin filaments. Capping protein...
متن کاملHow actin network dynamics control the onset of actin-based motility.
Cells use their dynamic actin network to control their mechanics and motility. These networks are made of branched actin filaments generated by the Arp2/3 complex. Here we study under which conditions the microscopic organization of branched actin networks builds up a sufficient stress to trigger sustained motility. In our experimental setup, dynamic actin networks or "gels" are grown on a hard...
متن کاملSpatial control of actin-based motility through plasmalemmal PtdIns(4,5)P2-rich raft assemblies.
The interactions of cells with their environment involve regulated actin-based motility at defined positions along the cell surface. Sphingolipid- and cholesterol-dependent microdomains (rafts) order proteins at biological membranes, and have been implicated in most signalling processes at the cell surface. Many membrane-bound components that regulate actin cytoskeleton dynamics and cell-surfac...
متن کاملActin-Based Cell Motility and Cell Locomotion
they move. Deadhesion/tail retraction may limit moveIntroduction ment rate in such cells. In weakly adhesive, fast moving Most animal cell types possess the capacity to move cells such as amoebae and white blood cells, the tail is over or through a substrate, and cell locomotion plays more rounded and this step is more efficient. Adhesion a key role in bothnormal physiology and disease.Certain ...
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ژورنال
عنوان ژورنال: Physical Biology
سال: 2013
ISSN: 1478-3967,1478-3975
DOI: 10.1088/1478-3975/10/6/066004