Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Interaction of Cisplatin with the human organic cation transporter 2.
PURPOSE Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation transporter 2 (OCT2) is highly expressed in the basolateral membrane of proximal tubules, we determined its contribution to cisplatin transport and assessed the relation of variation in the gene encoding OCT2 (SLC22A2) with the disposition of cisplatin. EXPERIMENTAL DESIGN...
متن کاملPharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2).
Publications: Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, DeLaCruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, and Giacomini KM (2003) Natural variation in human membrane trasporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci (USA) 100:5896-5901. Leabman MD, Huang CC, Kawamoto M, Johns SJ, Stryke D...
متن کاملKidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation.
Human organic cation transporter 2 (OCT2/SLC22A2), which is specifically expressed in the kidney, plays critical roles in the renal secretion of cationic compounds. Tissue expression and membrane localization of OCT2 are closely related to the tissue distribution, pharmacological effects, and/or adverse effects of its substrate drugs. However, the molecular mechanisms underlying the kidney-spec...
متن کاملNew Insight of OCT2 Regulation as Mediator for Cisplatin- Induced Nephrotoxicity
We read with interest the recently published review article in Asian Pac J Cancer Prev, by Nematbakhsh et al., entitled ‘Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences’(Nematbakhsh et al., 2017). The authors concluded several suggestions that may provide to reduce Cisplatin (CDDP) induced nephrotoxicity (Nematbakhsh et al., 2017). Here, we would like to add one ...
متن کاملAgmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).
Agmatine has received considerable attention recently. Available evidence suggests that agmatine functions as a neurotransmitter and inhibits, via induction of antizyme, cellular proliferation. Because of its positive charge, agmatine will not appreciably cross cellular membranes by simple diffusion. Indeed, all physiological models require a channel or transporter protein in the plasma membran...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 2009
ISSN: 0009-9236,1532-6535
DOI: 10.1038/clpt.2009.139