Contribution of apoe genetic variants to dyslipidemia

Background and Aims : To identify common rare genetic variants in APOE gene a cohort of subjects with primary hyperlipidemia compare them general population.Methods: A total 3180 unrelated consecutive were recruited the Lipid Unit at Hospital Universitario Miguel Servet, Zaragoza, Spain. Patients divided according to their lipid phenotype. 1426 patients diagnosed isolated hypercholesterolemia if triglycerides (TG) <200 mg/dL + LDL cholesterol (LDLc) ≥160 or apo B ≥120 mg/dL; 1515 mixed when TG ≥200 non-HDLc ≥190 239 hypertriglyceridemia TG≥200 <190 <120 376 considered normolipemic (TG LDLc <160 mg/dL). We also studied 822 random from Aragon Workers Health Study (AWHS), longitudinal study cardiovascular risk factors subclinical atherosclerosis, as population. In all subjects, exon 4 was sequenced clinical analytical variables registered.Conclusions: Ten different identified 30 hyperlipidemias, that not found controls neither AWHS cohort, suggesting they could be causally associated abnormalities. summary, our results suggest variability contributes etiology dyslipidemias, only dysbetalipoproteinemia. Methods: registered. Conclusions: