Continuous Thrombin Generation in Whole Blood: New Applications
نویسندگان
چکیده
منابع مشابه
The long-awaited whole-blood thrombin generation test.
Thrombin is a multifunctional protease that, in addition to hemostasis, supports other “nonhemostatic” mechanisms, such as the regulation of vascular permeability, vascular tone, inflammation, and angiogenesis. There is also evidence that thrombin plays a role in the pathogenesis and progression of liver fibrosis (1 ). Among the hemostasis functions played by thrombin, one may list the fibrinog...
متن کاملThrombin Generation in Zebrafish Blood.
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread...
متن کاملAutologous thrombin: intraoperative production from whole blood.
Thrombin is routinely combined in surgical practice with a fibrinogen source to prepare fibrin sealant to promote hemostasis or with platelet concentrates to prepare platelet gels to enhance wound healing. The purpose of this study was to evaluate the robustness and reproducibility of a new sterile handheld disposable thrombin-processing device (TPD) to generate autologous human thrombin in the...
متن کاملSimultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions.
Assays based on the formation of thrombin and fibrin are frequently used, and results are considered exchangeable in research/clinical settings. However, thrombin generation and fibrin formation do not always go hand in hand and flow profoundly influences thrombus formation. We describe the technical/clinical evaluation of an assay to simultaneously measure thrombin generation and fibrin format...
متن کاملWhole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.
BACKGROUND The calibrated automated thrombogram (CAT) assay in plasma is a versatile tool to investigate patients with hypo- or hypercoagulable phenotypes. The objective was to make this method applicable for whole blood measurements. METHODS Thin-layer technology and the use of a rhodamine 110-based thrombin substrate appear to be essential for a reliable thrombin generation (TG) assay in wh...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.4979.4979