Continuous infusion of beta-lactam antibiotics
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چکیده
منابع مشابه
Beta-lactam antibiotics in continuous infusion in critically ill patients
article [1], published in a recent issue of Critical Care, on the insuffi cient β-lactam concentrations in the early phase of severe sepsis and septic shock. While we fully agree with the authors’ fi ndings, we would like to off er some remarks. Only 18 of their 80 patients (22.5%) were infected with Pseudomonas aeruginosa, but Taccone and colleagues used the European Committee on Antimicrobial...
متن کاملContinuous infusion vs. bolus dosing: implications for beta-lactam antibiotics.
Beta-lactam antibiotics display time-dependant pharmacodynamics whereby constant antibiotic concentrations rather than high peak concentrations are most likely to result in effective treatment of infections caused by susceptible bacteria. Continuous administration has been suggested as an alternative strategy, to conventional intermittent dosing, to optimise beta-lactam pharmacokinetic/pharmaco...
متن کاملBeta-Lactam Antibiotics and Vancomycin Beta-lactam antibiotics
Anti-bacterial drugs have “selective toxicity”, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. For the ß-lactam drugs, this target is the cell wall. Mammalian cells lack cell walls, which for the bacteria are a critically important barrier protecting the organism from not only the vagaries of osmotic s...
متن کاملIs continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations.
The most important pharmacodynamic parameter for beta-lactam antibiotics has been shown to be the time above the MIC, which is used as an argument to administer beta-lactam antibiotics by continuous infusion. Studies in vitro and in laboratory animals comparing efficacy of continuous and intermittent infusion of beta-lactam antibiotics generally show continuous infusion to be more efficacious. ...
متن کاملContinuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial.
BACKGROUND Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with intermittent bolus dosing standard therapy, despite a strong theoretical rationale for continuous administration. The aim of this trial was to determine the clinical and pharmacokinetic differences between continuous and intermittent dosing in patients with severe sepsis. METHODS This was a prospective, d...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1992
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.36.12.2577