Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth
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چکیده
منابع مشابه
Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.
Mutational activation of Ras and a key downstream effector of Ras, the B-Raf serine/threonine kinase, has been observed in melanomas and colorectal carcinomas. These observations suggest that inhibition of B-Raf activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase (MEK) and the extracellular signal-regulated kinase MAPK cascade may be an effective a...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2007
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-06-0728