منابع مشابه
Repair at the nuclear periphery
T elomere association with nuclear pores is critical not only for transcriptional silencing but also for effi cient repair of double-stranded breaks in the subtelomeric region of budding yeast chromosomes, according to Therizols et al. (page 189). As in many organisms, yeast telomeres localize to the nuclear periphery. To determine whether nuclear pore proteins are involved in telomere tetherin...
متن کاملRepairing subtelomeric DSBs at the nuclear periphery.
Nuclear organization creates microenvironments favoring distinct nuclear functions. In budding yeast, silent chromatin regions such as telomeres are clustered at the nuclear periphery, creating zones of transcriptional repression. Recently, in the Journal of Cell Biology, Therizols et al. report that "telomere tethering at the nuclear periphery is essential for DNA double strand break repair in...
متن کامل"Knob" at the periphery of Descemet's membrane.
however is that the ustuall flat tissue between ai and the trabecula (b) may proje(t backwards as a knob (c). This swelling is granular and does not contain cells (Figs 2 and 3). Here this knob-like bulge has been -demonstrated in five eyes, three knobs w-ere normal and tw,o were malignant melanomata. Generally, the five cases (Figs 2-6), show the different structure of the knob, the prominent ...
متن کاملPrescribing practices of consultants at Karachi, Pakistan.
OBJECTIVE To audit the prescribing practices of consultants. DESIGN A randomized sample survey of 354 consultants prescription for analysis of some basic parameters as recommended by World Health Organization (WHO). MAIN OUTCOME MEASURES To provide feedback to the prescribers for promoting rational drug therapy. RESULTS The average number of drugs for prescription were found to be 4.51 an...
متن کاملCollinear facilitation and suppression at the periphery
Collinear facilitation is a common phenomenon in the fovea, but it has been recently challenged at the human periphery. Since physiological studies show that facilitation is found at the periphery but only from outside the receptive field, our hypothesis was that facilitation at the periphery exists but from larger target-flanker separations than the fovea. Here, we applied a recent paradigm (P...
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ژورنال
عنوان ژورنال: BMJ
سال: 1966
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5504.55-a