Construction of nano-assembly for mild photothermal therapy of tumors

Due to the high incidence and mortality rates of cancer, it is necessary seek more targeted effective treatment methods. Traditional cancer methods have problems such as incomplete significant side effects. In recent years, photothermal therapy (PTT) has been considered one most promising in biomedical field. The principle PTT use materials with conversion efficiency absorb near-infrared light (NIR) generate heat ablate tumors. advantages low toxicity, non-invasiveness, strong specificity, controllability. However, self-protective mechanism related shock proteins (HSPs) gives cells thermal tolerance. To minimize tolerance improve efficacy PTT, a nano-assembly composed Pluronic F-127 encapsulating HSP inhibitor APO photosensitizer Cy7-TCF developed. can accumulate at tumor site under irradiation. At same time, inhibits expression proteins, achieving effect mild reducing damage surrounding tissues.