Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
نویسندگان
چکیده
منابع مشابه
Cross-talk between constitutive and inducible nitric oxide synthases.
Nitric Oxide Synthases To the Editor, We read with great interest the recent work by Kanno et al1 describing the protective effect of nitric oxide (NO) against myocardial ischemia/reperfusion injury and were struck by the other phenomenon associated with it: superinduction of inducible NO synthase (iNOS) in endothelial NO synthase (eNOS) knockout mice. Although the exact mechanism is unknown an...
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Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present in all mammalian cells, the sheer volume of publications on the subject might lead one to conclude that this diminutive molecule is both omnipotent and omnipresent in human biology. This series of four Perspective articles, in the current and following issues of The Journal of Clinical Investigation , wi...
متن کاملOxygen reduction by nitric-oxide synthases.
Nitric-oxide synthases (NOS, EC 1.14.13.39) are hemeproteins that catalyze oxidation of L-arginine to NOz and L-citrulline. Three main isozymes exist in mammals that are regulated by distinct genes (1–6): a constitutive neuronal NOS (nNOS or NOS I), (7, 8), an endotoxinand cytokine-inducible NOS (iNOS or NOS II) (9, 10), and a constitutive endothelial NOS (eNOS or NOS III) (11). Although NOS ha...
متن کاملPerspective Series: Nitric Oxide and Nitric Oxide Synthases
Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present in all mammalian cells, the sheer volume of publications on the subject might lead one to conclude that this diminutive molecule is both omnipotent and omnipresent in human biology. This series of four Perspective articles, in the current and following issues of The Journal of Clinical Investigation , wi...
متن کاملMolecular architecture of mammalian nitric oxide synthases.
NOSs are homodimeric multidomain enzymes responsible for producing NO. In mammals, NO acts as an intercellular messenger in a variety of signaling reactions, as well as a cytotoxin in the innate immune response. Mammals possess three NOS isoforms--inducible, endothelial, and neuronal NOS--that are composed of an N-terminal oxidase domain and a C-terminal reductase domain. Calmodulin (CaM) activ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)54352-0