Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration
نویسندگان
چکیده
منابع مشابه
Creating a multi-center rare disease consortium – the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)
Eosinophilic gastrointestinal disorders (EGIDs) affect various segments of the gastrointestinal tract. Since these disorders are rare, collaboration is essential to enroll subjects in clinical studies and study the broader population. The Rare Diseases Clinical Research Network (RDCRN), a program of the National Center for Advancing Translational Sciences (NCATS), funded the Consortium of Eosi...
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INTRODUCTION T he eosinophilic gastroenteropathies are an interesting, yet somewhat poorly defined set of disorders that by definition include the infiltration of at least one layer of the gastrointestinal (GI) tract with eosinophils. First reported over 50 years ago, the clinical spectrum of these disorders was defined solely by various case reports. As these reports became more frequent, vari...
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Eosinophilic gastrointestinal disorders (EGID) are characterized pathologically by excess eosinophils in mucosal biopsies of one or multiple sites in the gastrointestinal (GI) tract, simultaneously or sequentially. Eosinophilic esophagitis (EoE) is the best characterized EGID, and in most patients it is an abnormal immune-mediated response to food antigens. Current recommendations for diagnosis...
متن کاملSerum Interleukin-17 Evaluation in Patients With Eosinophilic Gastrointestinal Disease
Background: Eosinophilic gastrointestinal disorders or diseases (EGIDs) may result from an abnormal immune-mediated response to food antigens. Activated eosinophils release various mediators with inflammatory properties which may result in tissue and subsequently organ damage. The cytokine milieu of these patients has revealed increased levels of pro-inflammatory cytokines, inc...
متن کاملTreatment adherence in pediatric eosinophilic gastrointestinal disorders.
OBJECTIVE Examine treatment adherence rates in pediatric eosinophilic gastrointestinal disorders (EGID). METHODS Participants were children aged 2.5-18 years with eosinophilic esophagitis or eosinophilic gastroenteritis (EGE) and their caregivers. A multimethod, multi-informant assessment including parent report and electronic monitoring was utilized, with a 90% cut point for nonadherence. ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2019
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2018.10.057