Consistent quantitative gene product expression: #3. Invariance with age
نویسندگان
چکیده
منابع مشابه
Consistent quantitative gene product expression: #3. Invariance with age
The quantitative expression of cell surface antigens and light scattering properties of five cellular reference populations in stressed bone marrow specimens were compared between pediatric and adult patients treated for acute myeloid leukemia (AML). The mean intensity of each antigen as well as the within patient and between patient variability showed striking consistency between the two diffe...
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Five reference populations in bone marrow specimens were identified by flow cytometry using specific combinations of reagents in order define the variation of gene product expression intensities both within and between individuals. Mature lymphocytes, uncommitted progenitor cells, promyelocytes, mature monocytes and mature neutrophils can be reproducibly identified as distinct clusters of event...
متن کاملConsistent quantitative gene product expression: #1. Automated identification of regenerating bone marrow cell populations using support vector machines
Identification and quantification of maturing hematopoietic cell populations in flow cytometry data sets is a complex and sometimes irreproducible step in data analysis. Supervised machine learning algorithms present promise to automatically classify cells into populations, reducing subjective bias in data analysis. We describe the use of support vector machines (SVMs), a supervised algorithm, ...
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Background & Objectives :Gastric cancer is 2-4 folds higher in men than women. Sex hormones are one of the leading causes of sexual dimorphism in incidence of gastric cancer. The aim of this study is to compare Cathepsin D and Caspase-7 gene expressions in the gastric tissue of normal men and women. Materials & Methods :In this cross-sectional study, gastric antrum tissue samples were collecte...
متن کاملGene expression becomes heterogeneous with age
Evidence from a number of fields indicates that phenotypic variation among individuals and among somatic cells increases with age [1–5]. However, no evidence for an age-dependent increase in variation in gene expression has yet been found [6–9]. Using eight microarray data sets from different studies in humans and rats, we find that gene expression becomes more variable with advancing age. This...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2016
ISSN: 1552-4922,1552-4930
DOI: 10.1002/cyto.a.22997