Consistent Biochemical Data are Essential for Comparability of Botulinum Toxin Type A Products

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Consistent Biochemical Data are Essential for Comparability of Botulinum Toxin Type A Products

The recent article from Dr Frevert of Merz, together with the accompanying commentary from Dr Sesardic of NIBSC, makes a new contribution to the data available for clinical botulinum toxin type A (BoNT-A) products. However, in addition to the comments about the various technical aspects of the data provided by Dr Frevert, as described by Dr Sesardic, one important and key factor about the BoNT-...

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Botulinum toxin type A (BoNTA) products are injectable biologic medications derived from Clostridium botulinum bacteria. Several different BoNTA products are marketed in various countries, and they are not interchangeable. Differences between products include manufacturing processes, formulations, and the assay methods used to determine units of biological activity. These differences result in ...

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ژورنال

عنوان ژورنال: Drugs in R & D

سال: 2011

ISSN: 1174-5886,1179-6901

DOI: 10.1007/bf03259798