Conserved Regions of the timeless (tim) Clock Gene in Drosophila Analyzed Through Phylogenetic and Functional Studies
نویسندگان
چکیده
منابع مشابه
Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies.
Circadian (approximately 24-hr) rhythms in Drosophila melanogaster depend upon cyclic expression of the period (per) and timeless (tim) genes, which encode interacting components of the endogenous clock. The per gene has been isolated from other insects and, more recently, a per ortholog was found in mammals where its expression oscillates in a circadian fashion. We report here the complete seq...
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Eukaryotic circadian clocks rely on transcriptional feedback loops. In Drosophila, the PERIOD (PER) and TIMELESS (TIM) proteins accumulate during the night, inhibit the activity of the CLOCK (CLK)/CYCLE (CYC) transcriptional complex, and are degraded in the early morning. The control of PER and TIM oscillations largely depends on post-translational mechanisms. They involve both light-dependent ...
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ژورنال
عنوان ژورنال: Genetics
سال: 1998
ISSN: 1943-2631
DOI: 10.1093/genetics/148.2.815