Conserved phosphorylation hotspots in eukaryotic protein domain families

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Almost all eukaryotic protein phosphorylation is conducted by a single superfamily of eukaryotic protein kinases (ePKs) that share a conserved catalytic domain. Several atypical protein kinases

Tony Hunter Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Almost all eukaryotic protein phosphorylation is conducted by a single superfamily of eukaryotic protein kinases (ePKs) that share a conserved catalytic domain. Several atypical protein kinases (aPKs) are also known, which lack sequence similarity to ePKs, although some have structural similarity to ePKs [1–3]. ...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2019

ISSN: 2041-1723

DOI: 10.1038/s41467-019-09952-x