منابع مشابه
New links between vesicle coats and Rab-mediated vesicle targeting.
Vesicle trafficking is a highly regulated process that transports proteins and other cargoes through eukaryotic cells while maintaining cellular organization and compartmental identity. In order for cargo to reach the correct destination, each step of trafficking must impart specificity. During vesicle formation, this is achieved by coat proteins, which selectively incorporate cargo into the na...
متن کاملSequential Coupling between CoplI and CopI Vesicle Coats in Endoplasmic Reticulum to Golgi Transport
COPI and COPII are vesicle coat complexes whose assembly is regulated by the ARF1 and Sarl GTPases, respectively. We show that COPI and COPII coat complexes are recruited separately and independently to E R (COPII), pre-Golgi (COPI, COPII), and Golgi (COPI) membranes of mammalian cells. To address their individual roles in E R to Golgi transport, we used stage specific in vitro transport assays...
متن کاملMembrane-coating lattice scaffolds in the nuclear pore and vesicle coats: commonalities, differences, challenges.
The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ∼30 nucleoporins (nups). Structural studies of the NPC have been limited by its considerable size and complexity. Progress toward understanding the structure of this nanomachine has benefited from its modular nature, which allows for this 40-6...
متن کاملSequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport
COPI and COPII are vesicle coat complexes whose assembly is regulated by the ARF1 and Sar1 GTPases, respectively. We show that COPI and COPII coat complexes are recruited separately and independently to ER (COPII), pre-Golgi (COPI, COPII), and Golgi (COPI) membranes of mammalian cells. To address their individual roles in ER to Golgi transport, we used stage specific in vitro transport assays t...
متن کاملStructure of Coatomer Cage Proteins and the Relationship among COPI, COPII, and Clathrin Vesicle Coats
COPI-coated vesicles form at the Golgi apparatus from two cytosolic components, ARF G protein and coatomer, a heptameric complex that can polymerize into a cage to deform the membrane into a bud. Although coatomer shares a common evolutionary origin with COPII and clathrin vesicle coat proteins, the architectural relationship among the three cages is unclear. Strikingly, the alphabeta'-COP core...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2010
ISSN: 0028-0836,1476-4687
DOI: 10.1038/4661048a