Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders
نویسندگان
چکیده
منابع مشابه
Stem cell transplantation in inherited metabolic disorders.
Allogeneic HSCT is performed for a small number of inborn errors of metabolism (IEM). Over the last years, transplantation outcomes have improved in this group of patients as the factors that predicted for poor transplantation outcomes were understood and addressed. The role of transplantation and its potential benefit for an individual patient with a certain IEM is therefore now much better de...
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Scientists fi rst described inborn errors of metabolism, also termed inherited disorders of metabolism, early in the 20th century and since then have determined the biochemical and genetic bases of a great number of these disorders both in humans and in an increasing number of companion animals. The availability of metabolic screening tests has advanced the biochemical and genetic characterizat...
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BACKGROUND Secondary cytopenias are serious complications following hematopoietic cell transplantation. Etiologies include myelotoxic agents, viral infections, and possibly transplant-related factors such as the intensity of the conditioning regimen and the source of stem cells. DESIGN AND METHODS We retrospectively analyzed data from 2162 hematopoietic cell transplant recipients to examine t...
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RATIONALE, AIMS AND OBJECTIVES The management of many inherited metabolic disorders (IMDs) is dependent on nutrition intervention, but few clinical management guidelines for these uncommon disorders exist. Clinicians are forced to make nutrition treatment decisions using limited data. This results in clinical variations in both service and cost. We describe a method for establishing management ...
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diagnosing inherited metabolic disorders is a joint effort of both clinical and laboratory disciplines. various aspects of metabolite, enzyme and mutation analysis will be discussed based on the experience of the metabolic section of the erasmus university medical centre. where should laboratory diagnosis start from? metabolite, enzyme or dna level? the emphasis will be on enzyme analysis of th...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2021
ISSN: 0268-3369,1476-5365
DOI: 10.1038/s41409-020-01179-5