Conjugation Reactions Involving Maleimides and Phosphorothioate Oligonucleotides
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چکیده
منابع مشابه
Conjugation reactions involving maleimides and phosphorothioate oligonucleotides.
Phosphorothioate diester oligonucleotides proved to be fully compatible with maleimides in the context of two different conjugation reactions: (a) reaction of (5')diene-[phosphorothioate oligonucleotides] with maleimido-containing compounds to afford the Diels-Alder cycloadduct; (b) conjugation of (5')maleimido-[phosphorothioate oligonucleotides] with thiol-containing compounds. No evidence of ...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2012
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc200598g