Conjugated-Polymer-Amplified Sensing, Imaging, and Therapy

Conjugated Polymer Nanoparticles in Bio- Sensing and Bio-Imaging

Quantification of amplified quenching for conjugated polymer microsphere systems.

A series of nonaggregating carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) have been synthesized for immobilization via electrostatic adsorption onto Eu3+-polystyrene microspheres with a mean diameter of 0.2 microm. This system is shown to constitute a ratiometric system that measures fluorescence quenching with high fidelity. The fluorescence quenching properties of the polymer-c...

Amplified fluorescence sensing of protease activity with conjugated polyelectrolytes.

Fluorescent conjugated polyelectrolytes with pendant ionic sulfonate and carboxylate groups are used to sense protease activity. Inclusion of the fluorescent conjugated polyelectrolyte into the assay scheme leads to amplification of the sensory response. The sensing mechanism relies on an electrostatic interaction between the conjugated polyelectrolyte and a peptide substrate that is labeled wi...

Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin

AIM To evaluate the potential of tumor-targeted nanoprobe, N-(2-hydroxypropyl)methacrylamide copolymer-conjugated zinc protoporphyrin (PZP) for photodynamic therapy (PDT) and tumor imaging. MATERIALS & METHODS Different tumor models including carcinogen-induced cancer were used, PZP was intravenously injected followed by irradiation with xenon or blue fluorescent light on tumor. RESULTS One...

Multifunctional Phosphorescent Conjugated Polymer Dots for Hypoxia Imaging and Photodynamic Therapy of Cancer Cells

Molecular oxygen (O2) plays a key role in many physiological processes, and becomes a toxicant to kill cells when excited to 1O2. Intracellular O2 levels, or the degree of hypoxia, are always viewed as an indicator of cancers. Due to the highly efficient cancer therapy ability and low side effect, photodynamic therapy (PDT) becomes one of the most promising treatments for cancers. Herein, an ea...