Congenital heart defects and maternal biomarkers of oxidative stress
نویسندگان
چکیده
منابع مشابه
Congenital heart defects and maternal biomarkers of oxidative stress.
BACKGROUND Women who have had pregnancies that were affected by nonsyndromic congenital heart defects have alterations in the homocysteine-methionine pathway that may indicate increased exposure to oxidative stress or reduced antioxidant defense or both. OBJECTIVE Our goal was to establish a maternal metabolic risk profile for nonsyndromic congenital heart defects that would enhance current p...
متن کاملMaternal homocysteine and congenital heart defects.
C S i o the Editor: An estimated 80% of congenital heart defects result rom an interaction between susceptibilities in parental and fetal enomes and environmental exposures including maternal lifestyle actors (1). We and others have recently reported that women who ave congenital heart defect-affected pregnancies have alterations n folate metabolism (2). This population-based case-control study...
متن کاملMaternal and foetal angiogenic imbalance in congenital heart defects.
AIMS Animal models showed that angiogenesis is related to abnormal heart development. Our objectives were to ascertain whether a relationship exists between congenital heart defects (CHDs) and angiogenic/anti-angiogenic imbalance in maternal and foetal blood and study the expression of angiogenic factors in the foetal heart. METHODS AND RESULTS Maternal and cord blood placental growth factor ...
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Chronic hypertension complicates ≈2% of pregnancies, but the effects of antihypertensive medication use on the developing fetus are not well understood. There is relatively consistent evidence that maternal hypertension, regardless of its treatment, is associated with a moderately increased risk of congenital heart defects (CHDs), but the question remains as to whether early pregnancy antihyper...
متن کاملMaternal Genome-Wide DNA Methylation Patterns and Congenital Heart Defects
The majority of congenital heart defects (CHDs) are thought to result from the interaction between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic mechanisms are attractive targets in the study of complex diseases because they may be altered by environmental factors and dietary interventions. We conducted a population based, case-control study of genome-wide mater...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2005
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/82.3.598