Conformational variation of calcium-bound troponin C
نویسندگان
چکیده
منابع مشابه
Conformational properties of cardiolipin-bound cytochrome c.
Interactions of cytochrome c (cyt c) with cardiolipin (CL) are important for both electron transfer and apoptotic functions of this protein. A sluggish peroxidase in its native state, when bound to CL, cyt c catalyzes CL peroxidation, which contributes to the protein apoptotic release. The heterogeneous CL-bound cyt c ensemble is difficult to characterize with traditional structural methods and...
متن کاملEffects of troponin I phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C.
Conformational exchange has been demonstrated within the regulatory domain of calcium-saturated cardiac troponin C when bound to the NH2-terminal domain of cardiac troponin I-(1-80), and cardiac troponin I-(1-80)DD, having serine residues 23 and 24 mutated to aspartate to mimic the phosphorylated form of the protein. Binding of cardiac troponin I-(1-80) decreases conformational exchange for res...
متن کاملCalcium Binding to the Low Affinity Sites in Troponin C Induces Conformational Changes in the High Affinity Domain
Residues 89-100 of troponin C (C8s-loo) and 96-116 of troponin 1 (196-116) interact with each other in the troponin complex (Dalgarno, D. C., Grand, R. J. A., Levine, B. A. Moir, A,, J. G., Scott, G. M. M., and Perry, S . V. (1982) FEBS Lett. 150, 54-58) and are necessary for the Caa+ sensitivity of actomyosin ATPase (Syska, H., Wilkinson, J. M., Grand, R. J. A., and Perry, S. V. (1976) Bioclre...
متن کاملImproved Genetically-Encoded Calcium Indicators Based on Troponin C
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متن کاملATP induces a conformational change in lipid-bound cytochrome c.
Resonance energy transfer studies using a pyrene-labeled phospholipid derivative 1-palmitoyl-2-[10-(pyren-1-yl)decanoyl]-sn-glycero-3-phosphoglycerol (donor) and the heme (acceptor) of cytochrome c (cyt c) have indicated that ATP causes changes in the conformation of the lipid-bound protein (Rytömaa, M., Mustonen, P., and Kinnunen, P. K. J. (1992) J. Biol. Chem. 267, 22243-22248). Accordingly, ...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 1999
ISSN: 0887-3585,1097-0134
DOI: 10.1002/(sici)1097-0134(19991201)37:4<510::aid-prot2>3.0.co;2-t