Confocal Raman spectroscopy: determination of natural moisturizing factor profile related to skin hydration

Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin.

In vivo confocal Raman spectroscopy is a noninvasive optical method to obtain detailed information about the molecular composition of the skin with high spatial resolution. In vivo confocal scanning laser microscopy is an imaging modality that provides optical sections of the skin without physically dissecting the tissue. A combination of both techniques in a single instrument is described. Thi...

Noninvasive assessment of the hydration gradient across the cornea using confocal Raman spectroscopy.

PURPOSE The feasibility of Raman spectroscopy for the noninvasive assessment of axial corneal hydration was investigated. METHODS A scanning confocal Raman spectroscopy system, with an axial resolution of 50 microns, was used to assess noninvasively the water (OH-bond) to protein (CH-bond) ratio as a measure of the hydration in collagen-based phantom media and rabbit corneas. RESULTS Raman ...

High Performance Method for Skin Roughness Detection Using Raman Spectroscopy

Effects of Natural Moisturizing Factor and Lactic Acid Isomers on Skin Function

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Confocal Raman spectroscopy: In vivo measurement of physiological skin parameters - A pilot study.

BACKGROUND In vivo application of confocal Raman spectroscopy (CRS) allows non-invasive depth measurement of the skin. Thereby obtained knowledge of the skin composition is essential to reliably assess the actual skin state. Besides other components, the skin cholesterol concentration is of interest; however, little is known about its connection to the cholesterol concentration quantified in ve...