Conditional likelihood score functions for mixed models in linkage analysis
نویسندگان
چکیده
منابع مشابه
Conditional likelihood score functions for mixed models in linkage analysis.
In this paper, we develop a general strategy for linkage analysis, applicable for arbitrary pedigree structures and genetic models with one major gene, polygenes and shared environmental effects. Extending work of Whittemore (1996), McPeek (1999) and Hossjer (2003d), the efficient score statistic is computed from a conditional likelihood of marker data given phenotypes. The resulting semiparame...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2005
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxi012