Concurrent Optical- and Magnetic-Stimulation-Induced Changes on Wound Healing Parameters, Analyzed by Hyperspectral Imaging: An Exploratory Case Series

The effects of concurrent optical and magnetic stimulation (COMS) therapy on wound-healing-related parameters, such as tissue oxygenation water index, were analyzed by hyperspectral imaging: an exploratory case series. Background: Oedema inadequate perfusion have been identified key factors in delayed wound healing linked to reduced mitochondrial respiration. Targeting dysfunction is a promising approach the treatment refractory wounds. This sub-study aimed investigate oedema through measuring using imaging. Patients methods: In multi-center, prospective, comparative clinical trial, eleven patients with chronic leg foot ulcers treated COMS additively Standard Care (SOC). Hyperspectral images collected during patient visits before after assess short- long-term hemodynamic immunomodulatory changes index. Results: average time for onset was 183 days, 64% them being considered unresponsive SOC. At week 12, rate near-complete complete closure 45%, respectively. SOC resulted increased short-term over 8-week phase, oxygen levels decreasing in-between visits. study further found decrease content therapy, general accumulation study’s analysis hindered lack absolute values imaging dynamic nature parameters visits, resulting high interpatient intervisit variability. Conclusions: showed that adjunct had positive effect inflammation wounds various etiologies. These results supported body evidence safety effectiveness option, especially stagnant tended stay inflammatory phase required efficient transition towards healing.