Concomitant 177Lu-DOTATATE and capecitabine therapy in malignant paragangliomas
نویسندگان
چکیده
منابع مشابه
SPECT image segmentation for estimation of tumour volume and activity concentration in 177Lu-DOTATATE radionuclide therapy
BACKGROUND Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows for imaging with SPECT (single photon emission computed tomography). One impo...
متن کاملAccuracy and precision assessment for activity quantification in individualized dosimetry of 177Lu-DOTATATE therapy
BACKGROUND In order to obtain a reliable 177Lu-DOTATATE therapy dosimetry, it is crucial to acquire accurate and precise activity measurements with the radionuclide calibrator, the SPECT/CT camera, and the NaI(Tl) well counter. The aim of this study was to determine, in a clinical context, the accuracy and the precision of their activity quantification over a range of activities and time. Ninet...
متن کاملMalignant and benign sinonasal paragangliomas.
OBJECTIVES/HYPOTHESIS To report on the clinical course and management of sinonasal paragangliomas (PGLs). STUDY DESIGN AND METHODS Retrospective chart review of six patients with PGLs of the nasal cavity and paranasal sinuses. RESULTS Three patients had tumors with malignant clinical behavior with cerebral metastases or infiltration of brain and local recurrence, despite surgery and/or radi...
متن کاملDose response of pancreatic neuroendocrine tumors treated with peptide receptor radionuclide therapy using 177Lu-DOTATATE.
UNLABELLED Peptide receptor radionuclide therapy (PRRT) is a promising treatment for patients with neuroendocrine tumors, giving rise to improved survival. Dosimetric calculations in relation to PRRT have been concentrated to normal organ dosimetry in order to limit side effects. However, the relation between the absorbed dose to the tumor and treatment response has so far not been established....
متن کاملA comparison of 2D and 3D kidney absorbed dose measures in patients receiving 177Lu-DOTATATE
Objective(s): To investigate and compare quantitative accuracy of kidney absorbed dose measures made from both 2D and 3D imaging in patients receiving 177LuDOTATATE (Lutate) for treatment of neuroendocrine tumours (NETs). Methods: Patients receiving Lutate therapy underwent both whole body planar imaging and SPECT/CT imaging over the kidneys at time points 0.5, 4, 24, and 96-120 hours after inj...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2019
ISSN: 2191-219X
DOI: 10.1186/s13550-019-0484-y