Concentrations of urinary neopterin, but not suPAR, positively correlate with age in rhesus macaques

Identifying biomarkers of age-related changes in immune system functioning that can be measured non-invasively is a significant step progressing research on immunosenescence and inflammaging free-ranging wild animal populations. In the present study, we aimed to investigate suitability two urinary compounds, neopterin suPAR, as activation inflammation rhesus macaque ( Macaca mulatta ) population. We also investigated age-associated variation gene transcription from blood samples understand underlying proximate mechanisms drive or suPAR. Neopterin was significantly positively correlated with age, had moderate within-individual repeatability, indicating it applicable biomarker changes. The are not apparently driven by an increase primary signaler neopterin, IFN-y, but may instead both CD14+ CD14− monocytes. suPAR low repeatability within-individuals, likely better suited measure acute rather than chronic increases (i.e., “inflammaging”). correlation 25%, they often signal different processes, which if disentangled could provide nuanced picture immune-system function when tandem.