Concentration-effect relationships and implications for trough-to-peak ratio

Reproducibility and Clinical Value of the Trough-to-Peak Ratio of the Antihypertensive Effect

The objectives of our study were to assess the reproducibility of the trough-to-peak ratio (T/P) and to see whether a high T/P is accompanied by more organ protection or vice versa. The study included 175 (mean6SD age, 5169 years) subjects with mild-moderate essential hypertension who had echocardiographic evidence of left ventricular (LV) hypertrophy taken from the SAMPLE study (Study on Ambul...

Peak and Trough.

Reproducibility and clinical value of the trough-to-peak ratio of the antihypertensive effect: evidence from the sample study.

The objectives of our study were to assess the reproducibility of the trough-to-peak ratio (T/P) and to see whether a high T/P is accompanied by more organ protection or vice versa. The study included 175 (mean+/-SD age, 51+/-9 years) subjects with mild-moderate essential hypertension who had echocardiographic evidence of left ventricular (LV) hypertrophy taken from the SAMPLE study (Study on A...

Dclcri~liiliilg lllc Trough-to-Peak Ratio in Parallel-Group Trials

~IIIII~\I-II)-~I~:I~ I:I!~II II 2,l.l i ~ ~ t l i v i t l ~ ~ ; ~ l s wit11 i ol;~ted sys~tdic ItyJICII~I I<~~II ( 2 6 0 YC:IIS) ~IIIIIIICII ill lllc ~ l : ~ c c l ~ o c o ~ ~ t ~ t ~ I I c t l SysIolic l l y ~ ~ c ~ l c ~ ~ s i t ~ ~ ~ ill ICIIIOII~ '1'ri:lI. Net !I~:I~IIICIII cll'ccts w c ~ e co111p111ctI by s ~ ~ l ~ l r : ~ c t i ~ ~ g tile IIC;II c11;111ges I'ro111 l ) ; ~sc l i ~~e t111ri...

Optimal Pharmacokinetics of Cyclosporine and Tacrolimus Based Relationship Among AUC, Trough and Peak Concentration

Calcineurin inhibitors (CNIs) are maintenance immunosuppressive drugs that have been used as the main therapy for organ transplantation for many years. Of the CNIs, cyclosporine (CYA) and tacrolimus (TAC) are used in clinical practice. The CYA binding protein is cyclophilin and that of TAC is FK-binding protein (FKBP), but both drugs have same mechanism of action: the inhibition of interleukin ...