Concanamycin A Specific Inhibitor of Vacuolar Type H^+-ATPases Induce B Cell Apoptosis
نویسندگان
چکیده
منابع مشابه
A novel subunit of vacuolar H(+)-ATPase related to the b subunit of F-ATPases.
The subunit structure of the vacuolar H(+)-ATPase (V-ATPase) membrane sector is not entirely known. The proteolipid is the only subunit that has been implicated in the mechanism of energy transfer in the enzyme. We have identified a protein (M16) that co-purifies with the V-ATPase complex from bovine chromaffin granules. Information obtained from the amino acid sequence of a proteolytic fragmen...
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Certain steroids having an oxo group at the C-17 or C-20 position such as pregnenolone and dehydroisoandrosterone inhibit the cholesterol transport from lysosomes to other cellular sites. Taking advantage of the fact that the inhibition is reversed upon removal of the steroids, we studied the factors that control the cholesterol transport from lysosomes to other cellular sites in macrophages. M...
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Growing evidence suggests a key role of tumor acidic microenvironment in cancer development, progression, and metastasis. As a consequence, the need for compounds that specifically target the mechanism(s) responsible for the low pH of tumors is increasing. Among the key regulators of the tumor acidic microenvironment, vacuolar H(+)-ATPases (V-ATPases) play an important role. These proteins cove...
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Function of V-ATPases The vacuolar (H)-ATPases (or V-ATPases) are a family of ATPdependent proton pumps that are responsible for acidification of intracellular compartments in eukaryotic cells (1–3). Acidification of vacuolar compartments plays an important role in a variety of cellular processes, particularly membrane traffic processes. In receptor-mediated endocytosis, acidification of endoso...
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ژورنال
عنوان ژورنال: The Journal of the Kyushu Dental Society
سال: 1996
ISSN: 0368-6833,1880-8719
DOI: 10.2504/kds.50.957