Computational methods and tools to predict cytochrome P450 metabolism for drug discovery
نویسندگان
چکیده
منابع مشابه
Medical Policy Subject: Genotyping - Cytochrome P450 (cyp450) for Drug Metabolism
PAGE: 1 OF: 9 • If a product excludes coverage for a service, it is not covered, and medical policy criteria do not apply. • If a commercial product, including an Essential Plan product, covers a specific service, medical policy criteria apply to the benefit. • If a Medicare product covers a specific service, and there is no national or local Medicare coverage decision for the service, medical ...
متن کاملComputational methods in drug discovery
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has mad...
متن کاملComputational methods in drug discovery.
Computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over three decades. These methods are broadly classified as either structure-based or ligand-based methods. Structure-based methods are in principle analogous to high-throughput screening in that both target and ligand structure information is imperative. Str...
متن کاملRole of Cytochrome P450 2C8 in Drug Metabolism and Interactions.
During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to metabolize more than 100 drugs. CYP2C8 substrate drugs include amodiaquine, cerivastatin, dasabuvir, enzalutamide, imatinib, loperamide, montelukast, paclitaxel, pioglitazone, repaglinide, and rosiglitazone, and the number is incr...
متن کاملPorcine cytochrome P450 and metabolism.
The pig and especially the minipig are becoming increasingly used as a test animal both in pharmacological and toxicological testing of new compounds. The minipig is used because of its size, it is easy to handle and less test substrate is required. When using an animal species for testing it is of importance to know if the test animal's posses the same abilities to metabolize drugs as humans. ...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2019
ISSN: 1747-0277,1747-0285
DOI: 10.1111/cbdd.13445