Computational brain connectivity mapping: A core health and scientific challenge

Computational brain connectivity mapping: A core health and scientific challenge

One third of the burden of all the diseases in Europe is due to problems caused by diseases affecting brain. Although exceptional progress have been obtained for exploring the brain during the past decades, it is still terra-incognita and calls for specific efforts in research to better understand its architecture and functioning. To take up this great challenge of modern science and to solve t...

Brain Network for the Core Deficits of Semantic Dementia: A Neural Network Connectivity-Behavior Mapping Study

Individuals with semantic dementia (SD) typically suffer from selective semantic deficits due to degenerative brain atrophy. Although some brain regions have been found to be correlated with the semantic impairments of SD patients, it is unclear if the damage is actually responsible for SD patients' semantic disorders because these findings were primarily obtained by examining the roles of loca...

Adolescent Pregnancy: A Health Challenge

Every year, some 3.9 million girls aged 15 to 19 years undergo unsafe abortions (1). Approximately 16 million girls aged 15 to 19 years and 2.5 million girls under 16 years give birth each year in developing regions (2, 3). Complications during pregnancy and childbirth are the leading cause of death for 15 to 19 year-old girls globally (4). Adolescent mothers (ages 10 to 19 years) face higher r...

Sleep apnea: Altered brain connectivity underlying a working-memory challenge

Computational Brain Connectivity Using Diffusion MRI

of “Computational Brain Connectivity Using Diffusion MRI” by Çağatay Demiralp, Ph.D., Brown University, May 2013. This dissertation shows that qualitative and quantitative characterization of patterned structures in brain connectivity data obtained using diffusion MRI not only improves the exploration of the intricate space of brain connectivity but also provides clinically meaningful measures,...