COMPRITOL® 888 LIPID MATRIX VIA TWIN SCREW EXTRUDER

Continuous Granulation with a Twin-Screw Extruder

Compritol 888 ATO: a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals.

INTRODUCTION Compritol® 888 ATO is a lipid excipient that is generally used in cosmetic industry as a surfactant, emulsifying agent and viscosity-inducing agent in emulsions or creams. Based on its chemical composition, Compritol 888 ATO is a blend of different esters of behenic acid with glycerol. AREAS COVERED Recently, there has been great interest in the multiple roles that Compritol 888 ...

Wet granulation in a twin-screw extruder: implications of screw design.

Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study endeavored to systematically examine t...

Modeling of Transport Phenomena and Melting Kinetics of Starch in a Co-Rotating Twin-Screw Extruder

A mathematical model was developed to simulate fluid flow, heat transfer, and melting kinetics of starch in a co-rotating intermeshing twin-screw extruder (TSE). The partial differential equations governing the transport phenomena of the biomaterial in the extruder were solved by a finite element scheme. For validating the model, the predicted product pressure, bulk temperature at the entrance ...

Aqueous extraction of residual oil from sunflower press cake using a twin-screw extruder: Feasibility study

The objective of this study was to evaluate the feasibility of an aqueous process to extract the residual oil from sunflower press cakes using a co-rotating twin-screw extruder. Two different configurations were tested: the expression fromwhole seeds followed by the aqueous extraction, in two successive apparatus or in the same one. For the aqueous extraction stage, the oil yield depended on th...