Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma

Sarcoma is a rare cancer with several subtypes; therefore, our understanding of the pathogenesis sarcoma limited, and designing effective treatments difficult. Circulating microRNAs (miRNAs), including exosomal miRNAs, have attracted attention as biomarkers in cancer. However, roles miRNAs exosomes remain unclear. The present analysis tissue serum miRNA expression osteosarcoma, Ewing's dedifferentiated liposarcoma (DDLPS) identified miR?1246, ?4532, ?4454, ?619?5p ?6126 for DDLPS. These were highly expressed human DDLPS cell lines exosomes, suggesting that they are secreted from tissues. results suggested specific may be used early diagnosis or treatment targets