Comprehensive Functional Genomic Profiling of HPV Unassociated Head and Neck Squamous Cell Cancer Identifies Neomorphic Mutations That Confer Resistance to Therapy
نویسندگان
چکیده
منابع مشابه
Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas.
PURPOSE The objective of this study is to investigate the significance of microRNAs (miRNA) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN A global miRNA profiling was done on 51 formalin-fixed archival HNSCC samples using quantitative reverse transcription-PCR approach, correlated with patients' clinical parameters. Functional characteriz...
متن کاملAuthor's response to reviews Title: Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck Authors:
Saskia M Wilting ([email protected]) Serge J Smeets ([email protected]) Peter JF Snijders ([email protected]) Wessel N van Wieringen ([email protected]) Mark A van de Wiel ([email protected]) Gerrit A Meijer ([email protected]) Bauke Ylstra ([email protected]) C René Leemans ([email protected]) Chris JLM Meijer ([email protected]) Ruud H Brakenhoff ([email protected]) Boudewijn JM Braakhu...
متن کاملCancer Therapy: Preclinical Development and Characterization of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma Tumorgrafts
Purpose: To develop a clinically relevantmodel system to study head and neck squamous cell carcinoma (HNSCC), we have established and characterized a direct-from-patient tumorgraft model of human papillomavirus (HPV)–positive and HPV-negative cancers. Experimental Design: Patients with newly diagnosed or recurrent HNSCCwere consented for donation of tumor specimens. Surgically obtained tissue w...
متن کاملBiomarkers of HPV in head and neck squamous cell carcinoma.
Human papillomavirus (HPV) is an accepted cause of head and neck squamous cell carcinoma (HNSCC), and patients with HPV-associated HNSCC have a favorable prognosis. Currently, there is no general guidance on the most appropriate biomarkers for clinical assessment of HPV in these malignancies. We compared PCR-based and serologic HPV assays, as well as p16 immunohistochemistry, individually and i...
متن کاملTLR4 down-regulation identifies high risk HPV integration in head and neck squamous cell carcinomas
1Department of Clinical and Experimental Medicine, Section of Pathological Anatomy, University of Foggia, Foggia, Italy, 2Laboratory of Preclinical and Translational Research, IRCCS-CROB, Oncological Reference Centre of Basilicata, Rionero in Vulture (PZ), Italy, 3Section of Pathological Anatomy, Polytechnic University of Marche, Ancona, Italy, 4Section of Pathological Anatomy, National Cancer ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2015
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2015.07.1925