Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database
نویسندگان
چکیده
منابع مشابه
PIBASE: a comprehensive database of structurally defined protein interfaces
MOTIVATION In recent years, the Protein Data Bank (PDB) has experienced rapid growth. To maximize the utility of the high resolution protein-protein interaction data stored in the PDB, we have developed PIBASE, a comprehensive relational database of structurally defined interfaces between pairs of protein domains. It is composed of binary interfaces extracted from structures in the PDB and the ...
متن کاملPiccolo, a Presynaptic Zinc Finger Protein Structurally Related to Bassoon
Piccolo is a novel component of the presynaptic cytoskeletal matrix (PCM) assembled at the active zone of neurotransmitter release. Analysis of its primary structure reveals that Piccolo is a multidomain zinc finger protein structurally related to Bassoon, another PCM protein. Both proteins were found to be shared components of glutamatergic and GABAergic CNS synapses but not of the cholinergic...
متن کاملCharacterization of Protein–Protein Interactions Using Atomic Force Microscopy
Atomic force microscopy (AFM), invented in 1986, expanded the application of scanning tunneling microscopy to nonconductive, soft, and live biological samples (Binnig et al., 1986; Hansma et al., 1988; Marti et al., 1988; Drake et al., 1989). AFM has several capabilities, including characterizing topographic details of surfaces from the submolecular level to the cellular level (Radmacher et al....
متن کاملPCPPI: a comprehensive database for the prediction of Penicillium–crop protein–protein interactions
Penicillium expansum , the causal agent of blue mold, is one of the most prevalent post-harvest pathogens, infecting a wide range of crops after harvest. In response, crops have evolved various defense systems to protect themselves against this and other pathogens. Penicillium -crop interaction is a multifaceted process and mediated by pathogen- and host-derived proteins. Identification and cha...
متن کاملInvestigation of Atomic Level Patterns in Protein—Small Ligand Interactions
BACKGROUND Shape complementarity and non-covalent interactions are believed to drive protein-ligand interaction. To date protein-protein, protein-DNA, and protein-RNA interactions were systematically investigated, which is in contrast to interactions with small ligands. We investigate the role of covalent and non-covalent bonds in protein-small ligand interactions using a comprehensive dataset ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2011
ISSN: 1471-2105
DOI: 10.1186/1471-2105-12-313