Component optimization of dairy manure vermicompost, straw, and peat in seedling compressed substrates using simplex-centroid design

Optimization of Carboxymethyl-Xyloglucan-Based Tramadol Matrix Tablets Using Simplex Centroid Mixture Design

The aim was to determine the release-modifying effect of carboxymethyl xyloglucan for oral drug delivery. Sustained release matrix tablets of tramadol HCl were prepared by wet granulation method using carboxymethyl xyloglucan as matrix forming polymer. HPMC K100M was used in a small amount to control the burst effect which is most commonly seen with natural hydrophilic polymers. A simplex centr...

formulation design and optimization of direct compressed tablets of cefuroxime axetil using experimental design

Floating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

Floating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

Fixture Design and Work Piece Deformation Optimization Using the Iterative Simplex Algorithm

Presents article is deal with optimization of the fixture for end milling process, the most important objective being the minimization of work piece deformation by changing the layout of fixture elements and the clamping forces. The main objective of this work has been the optimization of the fixtures Work piece deformation subjected to clamping forces for End milling operation. The present ana...