Complex Trait Locus Linkage Mapping in Atherosclerosis
نویسندگان
چکیده
منابع مشابه
Complex Trait Locus Linkage Mapping in Atherosclerosis
E ver since the initial proposal to use polymorphic DNA markers to map genetic diseases,1 linkage analysis (also called “positional cloning”) has been used successfully to find the gene defects for hundreds of monogenic Mendelian traits.2 Because monogenic diseases can serve as important models for understanding pathogenesis, especially if they point to novel biochemical and physiological pathw...
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E ver since the initial proposal to use polymorphic DNA markers to map genetic diseases,1 linkage analysis (also called “positional cloning”) has been used successfully to find the gene defects for hundreds of monogenic Mendelian traits.2 Because monogenic diseases can serve as important models for understanding pathogenesis, especially if they point to novel biochemical and physiological pathw...
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A novel and robust method for the fine-scale mapping of genes affecting complex traits, which combines linkage and linkage-disequilibrium information, is proposed. Linkage information refers to recombinations within the marker-genotyped generations and linkage disequilibrium to historical recombinations before genotyping started. The identity-by-descent (IBD) probabilities at the quantitative t...
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The mapping of loci underlying variation in quantitative traits is proving to be a powerful tool in genetic studies of animals and other organisms. Quantitative trait locus (QTL) mapping in crosses between genetically diverse lines has shown the presence of many QTL, as similarly have studies within livestock populations. Although much remains to be done with this type of analysis, higher resol...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000173307.25652.89