Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis

Susceptibility to Coxsackievirus B3-Induced Myocarditis in Mice

CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis

Studies on inflammatory disorders elucidated the pivotal role of the CX3CL1/CX3CR1 axis with respect to the pathophysiology and diseases progression. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. We therefore investigated the influence of CX3CR1 ablation in the model of acute myocarditis, which was induced by in...

RT-PCR Detection of Coxsackievirus B3: A Viral Myocarditis

Backgrounds and Aims: Coxsakievirus B3 (CVB3), one of the six Coxsakievirus B serotypes, is a member of the Enterovirus genus within the Picornaviridae family. CVB3 is an important pathogen of viral myocarditis, which accounts for more than 50% of viral myocarditis cases. The genome of CVB3, like that of other Entroviruses, is a single-stranded, sense, polyadenylated RNA molecule with 7400 nucl...

Myocarditis Role of CD1d in Coxsackievirus B3-Induced

gd T Cells Regulate Major Histocompatibility Complex Class II (IA and IE)-Dependent Susceptibility to Coxsackievirus B3-Induced Autoimmune Myocarditis

S. A. HUBER,* J. E. STONE, D. H. WAGNER, JR., J. KUPPERMAN, L. PFEIFFER, C. DAVID, R. L. O’BRIEN, G. S. DAVIS, AND M. K. NEWELL Department of Pathology and Immunobiology Program and Pulmonary Disease and Critical Care Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405; National Jewish Medical Research Center, Denver, Colorado 80206, and Department...