Complex genetic architecture in severe hypobetalipoproteinemia
نویسندگان
چکیده
منابع مشابه
The Complex Genetic Architecture of the Metabolome
Discovering links between the genotype of an organism and its metabolite levels can increase our understanding of metabolism, its controls, and the indirect effects of metabolism on other quantitative traits. Recent technological advances in both DNA sequencing and metabolite profiling allow the use of broad-spectrum, untargeted metabolite profiling to generate phenotypic data for genome-wide a...
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Maize (Zea mays) tassels underwent profound morphological changes during maize domestication and improvement. Although a number of genes affecting maize inflorescence development have been identified, the genetic basis of the morphological changes in maize tassels since domestication is not well understood. Here, using a large population of 866 maize-teosinte BC2 S3 recombinant inbred lines gen...
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the objective of this study was to compare six statistical methods for prediction of genomic breedingvalues for traits with different genetic architecture in term of gene effects distributions and number ofquantitative traits loci (qtls). a genome consisted of 500 bi-allelic single nucleotide polymorphism(snp) markers distributed over a chromosomes with 100 cm length was simulated. three differ...
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We review the genetics and pathophysiology of familial hypobetalipoproteinemia (FHBL), a mildly symptomatic genetically heterogeneous autosomal trait. The minority of human FHBL is caused by truncation-specifying mutations of the APOB gene on chromosome 2. In seven families, linkage to chromosome 2 is absent, linkage is instead to chromosome 3 (3p21). In others, linkage is absent to both APOB a...
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SUMMARY Understanding how interactions among set of genes affect diverse phenotypes is having a greater impact on biomedical research, agriculture and evolutionary biology. Mapping and characterizing the isolated effects of single quantitative trait locus (QTL) is a first step, but we also need to assemble networks of QTLs and define non-additive interactions (epistasis) together with a host of...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2018
ISSN: 1476-511X
DOI: 10.1186/s12944-018-0680-1