منابع مشابه
Protamine dosage effects on complement activation and sonoclot coagulation analysis after cardiac surgery
Background: An optimal dosage and infusion regime for protamine reversal of heparin after cardiopulmonary bypass is important. Methods: Protamine dosages of either 2mg/kg or 4mg/kg bodyweight were compared in 40 patients after first time coronary arterial bypass grafting. Protamine was infused with a syringe driver over 20 minutes. Arterial blood sampling was performed prior to and during surge...
متن کاملNo prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery.
OBJECTIVES Complement activation is considered an important mediator of myocardial ischaemia/reperfusion (I/R) injury. Although complement inhibitors are highly effective in animals, clinical trials fail to show a substantial benefit in humans. This raises questions on the role of complement activation in human myocardial I/R injury. METHODS Soluble C5b-9, i.e. terminal complement complex, an...
متن کاملCardiac anaphylaxis. Complement activation as an amplification system.
Complement is activated, and C3a and C5a anaphylatoxins are generated during hypersensitivity reactions clinically associated with cardiopulmonary collapse. The administration of C3a or C5a to nonsensitized isolated guinea pig hearts mimics the events caused by antigen challenge of sensitized hearts (i.e., cardiac anaphylaxis) in the absence of complement. Thus, complement-derived anaphylatoxin...
متن کاملAnesthesia Issues in Cardiac Surgery
The principle of anaesthesia for open-heart surgery is based on simplicity, safty and lightplane of anaesthesia. As a result of the special pathophysiology, grave general status, complications threatening these patients during and after the operation and the abundance of medicines available nowadays, it is very important for the anaesthetist to be acquainted with the pathophysiological and ph...
متن کاملComplement Activation
The complement system is the most important biochemical cascade in the blood for the recognition, opsonization, and elimination of foreign materials. To date, the leading causes of death in the United States include cancer, cardiovascular and neurodegenerative diseases, and diabetes. New treatments are urgently needed to treat these devastating diseases and nanotechnology potentially provides n...
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ژورنال
عنوان ژورنال: Anesthesia & Analgesia
سال: 2012
ISSN: 0003-2999
DOI: 10.1213/ane.0b013e3182652b7d