Competitive inhibition of phospholipase A2 in vesicles
نویسندگان
چکیده
منابع مشابه
Inhibition of phospholipase A2.
Phospholipases A2 are involved in inflammatory processes such as the liberation of free arachidonic acid from the membrane pool for the biosynthesis of eicosanoids. Inhibitors of these enzymes are proving useful in determining the biological roles of phospholipases A2 in complex cellular processes and may also have therapeutic potential. Inhibition of these lipolytic enzymes is more difficult t...
متن کاملPhospholipase A2 inhibition results in sequestration of plasma membrane into electronlucent vesicles during IgG-mediated phagocytosis.
Arachidonic acid is essential for antibody-mediated phagocytosis but its role in this process has not been defined. The phospholipase A2 inhibitor bromoenol lactone decreases arachidonic acid release and arrests phagocytosis; this effect is bypassed by the addition of arachidonic acid to bromoenol lactone-treated cells. In this morphological study, monocytes treated with bromoenol lactone accum...
متن کاملNicotine-induced inhibition of neuronal phospholipase A2.
A protective effect of nicotine against glutamate-induced neurotoxicity has previously been reported in cultured striatal and cortical neurons. The aim of this study was to investigate whether nicotine also inhibits glutamate-evoked arachidonic acid release from cultured striatal neurons. (-)-Nicotine selectively inhibited the release of [3H]-arachidonic acid induced by the joint stimulation of...
متن کاملInhibition of beta-bungarotoxin action by bee venom phospholipase A2.
(3-Bungarotoxin ((3-BuTX) induces twitching of innervated frog muscle and subsequently blocks transm itter release from motor nerve endings. These actions of P-BuTX are prevented if the nerve-muscle junctions are pretreated with a low concentration of phospholipase A2 from bee venom. When the Ca2+ in the external fluid is replaced by Sr2+, the phospho lipase activity of P-BuTX is negligible an...
متن کاملFunction and inhibition of intracellular calcium-independent phospholipase A2.
Our previous Minireview (1) considered the three main kinds of phospholipase A2 (PLA2) : the well characterized Groups I, II, and III small Ca-dependent secretory phospholipase A2s (sPLA2), the 85-kDa Group IV Ca -dependent cytosolic phospholipase A2 (cPLA2), and the 80-kDa Ca -independent cytosolic phospholipase A2 (iPLA2). In the ensuing years, it has become clear that PLA2 represents a growi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemistry
سال: 1989
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi00436a002