Comparison of the Hepatotoxicity of Carbamazepine, Sodium Valproate, Phenytoin, Lamotrigine, and Vigabatrin in a Rat Model

Background: Hepatotoxicity is one of the most important side effects anticonvulsant drugs. This study compared hepatotoxicity sodium valproate, carbamazepine, phenytoin, lamotrigine, and vigabatrin in male rats. Methods: Based on results, 56 rats were randomly divided into seven groups eight treated intraperitoneally for four weeks. Groups 1 2 received 500 mg/kg carbamazepine 3, 4, 5 injected with 200 vigabatrin, respectively. As control groups, sixth seventh distilled water sesame oil. Biochemical parameters such as alanine aminotransferase (ALT), aspartate transaminase (AST), γ-glutamyl transferase (GGT) serum samples, well malondialdehyde (MDA) glutathione (GSH) contents liver homogenates, measured at end experiment. Results: MDA levels phenytoin significantly higher than that (P<0.05). GSH meaningfully to valproate (P<0.05), (P<0.001). GGT level group was remarkably comparison other (P<0.01). ALT AST represented considerably Conclusion: Overall, carbamazepine-induced caused significant changes GSH, GGT, AST. The induction had least effect enzymes different groups. Because no hepatic metabolism, biomarkers did not demonstrate a considerable difference between