Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer.

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منابع مشابه

Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer.

Thirty published studies of the clinical pharmacology of gastric antisecretory agents in normal volunteers and duodenal ulcer patients were reviewed. The aim was to investigate the relationship between antisecretory effect in the two populations. There was a significant correlation between effect in patients and normal subjects for suppression of 24 hour intragastric acidity (r = 0.732; p = 0.0...

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Duodenal inhibition of gastric secretion by osmotic agents in normal subjects and patients with duodenal ulcer.

Gastric secretion in man is inhibited by the presence in the duodenum of hyperosmolar and hypoosmolar solutions. Both acid and pepsin outputs are affected. There is no change in hydrogen, sodium, or potassium ion concentration in the gastric juice. Pepsin concentration, however, is reduced by all inhibitory stimuli. Inhibition is thought to act directly upon parietal and chief cells, and a poss...

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ژورنال

عنوان ژورنال: Gut

سال: 1986

ISSN: 0017-5749

DOI: 10.1136/gut.27.9.1058