Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet

Novel sulpiride-loaded solid lipid nanoparticles with enhanced intestinal permeability

BACKGROUND Solid lipid nanoparticles (SLN), novel drug delivery carriers, can be utilized in enhancing both intestinal permeability and dissolution of poorly absorbed drugs. The aim of this work was to enhance the intestinal permeability of sulpiride by loading into SLN. METHODS A unique ultrasonic melt-emulsification method with minimum stress conditions was used for the preparation of SLN. ...

Formulation & Evaluation of Gemcitabine Hydrochloride Loaded Solid Lipid Nanoparticles

INTRODUCTION Gemcitabine hydrochloride is an antimetabolite (pyrimidine analog) with poor oral bioavailability (9%) due to the first pass metabolism. GEM is a water soluble drug (log p = -1.4) with a short half-life of 42 to 94 minutes (short infusions) and 245 to 638 minutes (long infusions) respectively. Extensive first pass metabolism, low bioavailability, high dosing frequency and less half...

Simultaneous Estimation of Nebivolol Hydrochloride and Valsartan using RP HPLC

In this study, a rapid, precise, accurate, specific and sensitive ion-paired reverse phase liquid chromatographic method has been developed for the simultaneous estimation of nebivolol hydrochloride and valsartan in their capsule formulation. The chromatographic method was standardized using a HIQ sil C(18) column (250x4.6 mm i.d., 5 mum particle size) with UV detection at 289 nm and flow rate ...

solid lipid nanoparticles of ciprofloxacin hydrochloride with enhanced antibacterial activity

Synergistic Effect of Chemical Enhancer And Iontophoresis For Transdermal Delivery Of Nebivolol Hydrochloride

The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...