Comparison of Efficacy and Safety of BEAC BEAM and Be-EAM Conditioning Regimens Prior to Autologous Stem Cell Transplantation in Lymphoma

Autologous hematopoietic stem cell transplantation is recommended and significantly improved the prognosis of lymphoma patients. However, preferred conditioning regimen prior to autologous still a controversial topic. Current experiment was aim explore efficacy safety BEAC (carmustine, etoposide, cytarabine cyclophosphamide), BEAM melphalan) Be-EAM (bendamustine, cytarabine, etoposide preparative regimens in patients who underwent transplantation. 19 cases were enrolled followed-up for 13 mo, 6 treated with BEAC, 5 8 Be-EAM. We found median progression free survival 23 mo group, but overall other 2 groups had not been reached due short follow-up time. The achieved neutrophil platelet engraftment 12.500 15.167 d 11.200 14.000 group cohort 11.250 11.750 d. Statistically differences on observed comparing regimens. Additionally, volume transfusion least three groups. main adverse events included bone marrow suppression, fever, mucositis, nausea vomiting all them acceptable. favorable received treatment has shorter hospital stay, faster reconstitution, fewer infusions superiority storage conditions drug cost bendamustine, could be potential optimistic option treatment.