Comparison between hematological and biochemical changes caused by conventional and metronomic chemotherapies in the treatment of canine transmissible venereal tumor

ABSTRACT: This study aimed to report the hematological and biochemical changes caused by conventional metronomic chemotherapies, using vincristine sulfate treat canine Transmissible Venereal Tumor (TVT). Twelve dogs were selected, six of them for group receiving chemotherapy (G1), (G2). The G1 received once a week at dose 0.75mg/m² until tumor had disappeared with treatment, G2 was treated three times 0.25mg/m2 disappeared. Before after blood tests performed evaluate main alterations both chemotherapeutic models. Dogs undergoing significant leukocyte (p<0.05), causing neutropenia leukopenia. In chemotherapy, leukocytes remained within reference range. Half in normochromic, normocytic anemia. only alteration observed increase urea G2. Thus, treatment TVT proved be an excellent method fewer adverse effects, especially maintaining leukogram normal range reducing number anemia animals during treatment.