COMPARISON BETWEEN ADRENALINE AND WITHOUT ADRENALINE SOLUTION ON BLEEDING CONTROL OF SKIN GRAFT DONOR SITE: A RANDOMIZED CONTROLLED TRIAL

OBJECTIVE: To compare the bleeding control of skin graft donor site between normal saline soaked gauze with adrenaline and conventional technique having no adrenaline. METHODS: This open-label randomized trial was conducted at Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan from October 2020 to March 2021. Seventy-five patients were interventional (n=36, 48%) group (n=39, 52%) through sealed envelopes. Diluted solution prepared by adding 30cc Ringer’s lactate 10cc lignocaine 2%, 1cc 1:200000 200 ml solution. Solution for containing only saline. Following harvesting site, a piece tumescent applied wound. Bleeding severity epithelialization assessed. Data recorded in pre-designed performa analyzed SPSS version-25. RESULTS: There significant differences baseline characteristics like age (p=0.823), gender (p=0.984) nature injury (p=0.936) among two groups. Severe, moderate mild noted 20/39 (51.3%), 15/39 (38.5%) 4/39 (10.3%) cases as compared 0/36 (0%); 2/36 (5.6%) 25/36 (69.4%) respectively (**<0.001). No 9/36 (25%) group. Complete observed 24/36 (66.7%) & 17/39 (43.6%) groups (p=0.045). CONCLUSION: Application more effective early following technique.