Comparing the Effectiveness of Metoclopramide, Low Dose of Propofol, Ondansetron, and Magnesium Sulfate on Propofol Injection Pain: A Double-Blind Clinical Trial

Objectives: Despite a variety of strategies, propofol injection pain (PIP) is still one the most distressing adverse effects drug. This study aimed to compare effectiveness metoclopramide, low dose propofol, magnesium sulfate, and ondansetron in prevention PIP. Materials Methods: double-blind clinical trial was conducted at Al-Zahra hospital an academic referral center affiliated with Guilan University Medical Sciences, Rasht, Iran. A total 120 eligible women candidates for elective gynecologic surgeries were divided into four equal groups sulfate (30 mg/kg), (4 mg), metoclopramide (10 (15 mg). The primary outcome this decrease severity injection. Results: participants’ demographic characteristics, including age, American Society Anesthesiologists classification, body mass index, had no significant differences between groups. heart rate mean arterial pressure observed groups; however, difference insignificant. intensity group 1.57 ± 0.9, 1.37 0.89, 0.95 0.93, 1.25 1.1 (P=0.036). Conclusions: Metoclopramide could appropriately alleviate Considering some additional advantages, antiemetic properties, preventing esophageal reflux, less risk postoperative ileus, drug be safe acceptable choice.