Comparative Study on Nobiletin Metabolism with Liver Microsomes from Rats, Guinea Pigs and Hamsters and Rat Cytochrome P450
نویسندگان
چکیده
منابع مشابه
Metabolism of 2,2',3,4',5,5'-hexachlorobiphenyl (cb146) by Liver Microsomes from Rats, Hamsters and Guinea Pigs
Introduction Some hydroxy (OH)-metabolites of various PCB congeners such as 4-OH-2,2',3,4',5,5',6-heptachlorobiphenyl (CB187), 4-OH-2,2',3,4',5,5'-hexachlorobiphenyl (hexaCB) (CB146), 4-OH-2,3,3',4',5-pentachlorobiphenyl (CB107), 3'-OH-2,2',3,4,4',5'-hexaCB (CB138) and 3-OH-2,2',4,4',5,5'-hexaCB (CB153) have been found in human blood at higher concentrations. Recent studies have shown that such...
متن کاملEffects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.
Flavonoids are widely occurring in our diet. In this study, the effects of nine flavonoids on acetaminophen (APAP) oxidation and related cytochrome P450 (P450) enzyme activities were investigated. With rat liver microsomes, APAP oxidation was stimulated 2- to 4-fold by 50 microM flavone or tangeretin and inhibited 65% by myricetin or quercetin. Only a slight inhibition of APAP oxidation was cau...
متن کاملMetabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes.
One of the factors determining the toxicity of chlorpyrifos (CPS), an organophosphorus (OP) insecticide, is its biotransformation. CPS can be activated by cytochrome P450 (CYP) through a desulfuration reaction to form chlorpyrifos-oxon (CPO), a potent anticholinesterase. CPS can also be detoxified by CYP through a dearylation reaction. Using pooled human liver microsomes (HLM), a K(m(app)) of 3...
متن کاملMetabolism of sesamin by cytochrome P450 in human liver microsomes.
Metabolism of sesamin by cytochrome P450 (P450) was examined using yeast expression system and human liver microsomes. Saccharomyces cerevisiae cells expressing each of human P450 isoforms (CYP1A1, 1A2, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, and 3A4) were cultivated with sesamin, and monocatechol metabolite was observed in most of P450s. Kinetic analysis using the microsomal fractions of the...
متن کاملComparative metabolism of 2,6-dimethylnitrosomorpholine in rats, hamsters, and guinea pigs.
The metabolism of N-[3,5-3H]nitroso-2,6-dimethylmorpholine (NDMM) was studied in female Sprague-Dawley rats. Syrian golden hamsters, and guinea pigs. NDMM induces tumors in the esophagus in rats, pancreatic cancer in hamsters, and hemangioendothelial tumors of the liver in guinea pigs. An intragastric dose of NDMM (2 mg, 2 muCi/animal) was rapidly distributed throughout the tissues of both the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2007
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.30.2317