Comparative genomics reveals gene-specific and shared regulatory sequences in the spermatid-expressed mammalian Odf1, Prm1, Prm2, Tnp1, and Tnp2 genes
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چکیده
منابع مشابه
P-209: Decreased Expression of Histone Acetyltransferase CDY1 Gene in Testis Tissue May Lead to Decreased Expression of Transition Protein (TNP) and Protamine (PRM) Genes,Causing Male Infertility
Background: Infertility is a complex medical problem. About 15% of couples are infertile, and male infertility being involved in roughly 50% of the cases. Among these, many cases are associated with a severe impairment of spermatogenesis. During the last stage of spermatogenesis (spermiogenesis), sperm chromatin endures complex modifications in which histones are lost and depositioned with tran...
متن کاملAssociation study of six SNPs in PRM1, PRM2 and TNP2 genes in iranian infertile men with idiopathic azoospermia
BACKGROUND Histones are replaced by protamines to condensate and package DNA into the sperm head during mammalian spermatogenesis. Protamine genes defects have been reported to cause sperm DNA damage and male infertility. OBJECTIVE In this study relationship among some protamines genes family SNPs include PRM1 (C321A), PRM2 (C248T) and TNP2 (T1019C), (G1272C), (G del in 1036 and 1046 bp) were...
متن کاملHaploid transcripts persist in mature human spermatozoa.
Mammalian spermiogenesis is marked by the morphological and functional differentiation of round haploid spermatids into mature spermatozoa. A molecular restructuring of the chromatin accompanies this process facilitated by the transition proteins and protamines which compact and condense the genetic material within the developing spermatid. Previous studies from this laboratory have demonstrate...
متن کاملP-207: Study of Relationship among Six SNPs in PRM1, PRM2 and TNP2 Genes and Idiopathic Azoospermia in Iranian Infertile Men
Background: Histones are replaced by protamines to condensate and package DNA into the sperm head during mammalian spermatogenesis. Protamine genes defects have been reported to cause sperm DNA damage and male infertility. In this study relationship among some protamines genes family SNPs include PRM1 (C321A), PRM2 (C248T) and TNP2 (T1019C), (G1272C), (G del in 1036 and 1046 bp) were studied in...
متن کاملassociation study of six snps in prm1, prm2 and tnp2 genes in iranian infertile men with idiopathic azoospermia
background: histones are replaced by protamines to condensate and package dna into the sperm head during mammalian spermatogenesis. protamine genes defects have been reported to cause sperm dna damage and male infertility. objective: in this study relationship among some protamines genes family snps include prm1 (c321a), prm2 (c248t) and tnp2 (t1019c), (g1272c), (g del in 1036 and 1046 bp) were...
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ژورنال
عنوان ژورنال: Genomics
سال: 2008
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2008.05.001