COMPARATIVE ANALYSIS OF PLASMA OREXIN A AND OREXIN B LEVELS IN PEDIATRIC MIGRAINE PATIENTS: A PROSPECTIVE CONTROLLED CLINICAL STUDY

Objective: Migraine is the most common primary headache disorder in children. However, its pathogenetic mechanisms are not fully understood. Researchers focused on Orexin A (a neuropeptide with anti-nociceptive effects) and B pro-nociceptive effects), but literature scarce terms of studies investigating plasma levels these neuropeptides pediatric migraine patients. We aimed to compare orexins between patients healthy controlsMethods: Children aged 5 18 who were under diagnostic evaluation for diagnosed Ondokuz Mayıs University, Department Pediatric Neurology December 2018 2019, constituted target population. All study group (Group 1) according IHS 2004 criteria. The control 2) consisted Data including age, gender, presence or absence aura recorded. Two blood samples taken from Group 1. first sample was withdrawn during a non-attack period, second initial attack. Only one sampling done group. Plasma analyzed by radioimmunoassay compared 1 2 attack periods. Also, intra-group comparative analyses performed. Non-parametric tests used statistical analysis.Results: This included 98 patients, 52 children 1), 46 2). Mean patient age 12,5±3,1 year 12,3±3,4 years 2. There no difference groups gender (p=0,103) (p=0,734). higher than participants while period. mean level significantly period (p=0,002). did impact orexin both periods.Conclusions: elevated probably as response nociceptive signals, associated levels. Targeting orexinergic system seems like reasonable approach improving treatment disease.