Comorbidities and health-related quality of life in Patients with Antineutrophil Cytoplasmic Antibody (ANCA) - associated vasculitis

The optimization of immunosuppressive therapies has led to a marked improvement in the survival ANCA-associated vasculitides (AAV). main issue now appears be management comorbidities and quality life. objective this review was investigate incidence impact AAV-associated comorbidities, as well determinants health-related life (HRQoL). We performed systematic literature articles published Medline from 2001 04/28/2020. selected relevant about HRQoL fatigue. For each article, data on comorbidity were extracted, factors associated with Mental component score (MCS) Physical (PCS) identified. Among 10,993 references identified, 103 retained for final analysis. A significant increase cardiovascular risk evidenced, particularly coronary artery disease thromboembolic events, especially during active phase disease. AAV also bronchiectasis, thyroid diseases osteoporosis. decrease an fatigue anxiety reported. Decrease PCS MCS fatigue, mood disorders, sleep disturbance, and/or unemployment. excess mortality is still concern, partly connection comorbidities. patients experiment reduction their that requires integrated management. Patients need strategies improve outcomes.